Chapter 266:
Tsunade, one of the legendary Sannin, was Orochimaru's legitimate wife in Konoha.
The two weren't just bound by the title of husband and wife; their relationship had been real and tangible.
Back when Orochimaru defected from the village, Tsunade had been ready to leave Konoha and follow him.
But Konoha was home to her younger brother, Nawaki.
It was Orochimaru himself who convinced her to stay, though doing so created a deep rift between Tsunade and the Third Hokage.
Even Jiraiya, known for his forgiving and easygoing nature, was helpless when it came to the tension that arose from this situation.
Disheartened and estranged, Tsunade drifted into a state of depression. Her daily life in Konoha became increasingly bleak and decadent.
The Third Hokage had wanted to help her, but Tsunade's emotional state left her unable to resume her former role. The once-close bond between master and disciple had slowly eroded.
Now, with war raging once again, Tsunade found herself unable to contact Orochimaru. This only deepened her anxiety and frustration.