I Survived in Anbu to Become Super Kage

Orochimaru had developed a special hallucinogenic drug to deal with jinchuriki; a single pill had directly killed the Eight-Tails Jinchuriki, Bunobi.

The smoke bomb Shinba threw contained Orochimaru's hallucinogen. With its massive lung capacity, the Five-Tails inhaled a large amount of the smoke.

Hatake Sakumo looked up and saw the Five-Tails' eyes change drastically.

Before, its eyes had been filled with a desire for freedom and a deep disgust for the Iwa Ninjas.

Now, the beast's eyes were fierce and cruel, clearly agitated by the drug.

It threw its head back and let out a resonant howl. The cry was so high-pitched and drawn out that the Five-Tails' voice grew slightly hoarse by the end.

"Retreat! Retreat immediately!"

Seeing the Five-Tails go berserk, the Konoha ninjas hastily leaped away into the distance.

After retreating to a safe distance, Hatake Sakumo stared in stunned silence at the frenzied Five-Tails before turning to look at Shinba.